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Peptide-based therapeutics have emerged as promising alternatives, offering high specificity, favorable safety profiles, and unique biological activities compared to traditional treatments

Besides being responsible for base-acid homeostasis, CA II is suggested to be involved in myelin metabolism and compaction since it is also activated during developmental myelination (Delaunoy et al., 1980

All studies that did not fulfil all eligibility criteria were excluded from further analysis

Other metabolic peptides and drugs work through different pathways

For most older adults with mild-to-moderate deficiency, no, high-dose oral or sublingual B12 corrects deficiency as well as injections in randomized trials