why injections for depleted vitamin b12 Seeing Red: Do Work? B12 Injection Dose: 7 Guidelines
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Vitamin injections are generally safe when administered by trained medical professionals and when the injection is appropriate for the client

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They may also be necessary when certain medications interfere with B12 absorption or in any other diagnosed condition specifically impacting B12 uptake

One would surely argue that some groups are more at risk for B12 deficiencies and could, therefore, benefit from injections: vegetarians and vegans have impaired B12 absorption due to changes from diet, while older adults have changes due to aging