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Inhalable dry powders of siRNAloaded lipidpolymer hybrid nanoparticles with trehalose, and miR335loaded EVs with trehalose and leucine are prepared by spray drying and thinfilm freezedrying, respectively, both of which exhibit excellent aerosolization properties (MMAD: 2.96 m, FPF: 65%

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Medicare Advantage insurers spend about $12 billion on Part B drugs, compared to with the $25.7 billion traditional Medicare spent in 2016 on such drugs