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L-karnitin tez-tez tibb v salamlq qidalarnda, idman ikilrind, uaq qidalanmasnda v heyvan qidasnda istifad olunur [Qabladrma] 1

Yang, F., Chen, C., Ni, D., Yang, Y., Tian, J., Li, Y., Chen, S., Ye, X., & Wang, L

doi: 10.1016/j.biopha.2021.111315 194 JiaoPMaJFengBZhangHDiehlJAChinYEet al

Given that skeletal muscle is the major site of carnitine storage within the body, and that maintaining hypercarnitinemia for 5h in the presence of hyperinsulinemia increases skeletal muscle TC accumulation (other Stephens Group studies), it is not unreasonable to suggest that this greater retention occurred mainly in this tissue. Given that the increase in muscle carnitine content following a single dose, or 2 weeks, of L-carnitine feeding in the presence of elevated circulating insulin is likely to be small due to the poor bioavailability of orally administered L-carnitine (less then 20%), muscle carnitine accumulation was estimated indirectly from measurements of plasma and urinary carnitine concentration

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