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Pulm Pharmacol Ther 15: 103-110

Also, any lump should be biopsied if it is felt to be getting larger rather than smaller one month after its discovery

So, while the debate between localized and systemic application will likely continue, the most consistent and logically sound approach for targeted ankle research points toward a localized, subcutaneous injection near the site of injury

Eur J Pharmacol 2005
