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Osmotic gradients are the results of active transport of bile acids from hepatocytes in the periportal zones of the lobule (this process is responsible for the bile acid-dependent bile flow), and transport of glutathione (GSH) and other solutes from the distal hepatocytes of the lobule (pericentral lobular cells

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Rather than forcing the skin to peel, they "signal" the skin to repair its own foundation
(2007) 292:H66672
