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Here G denotes the Gibbs free energy, but a similar expression would hold for Helmholtz free energy depending on the choice of ensemble

Thus, elevated levels or activity of these mediators might provide an explanation for CD38 upregulation noted in SSc skin biopsies 24

While these findings are promising, it is crucial to emphasize that clinical research on MOTS-c in humans remains limited

The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations

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