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More recently, Joseph Kanner (also present in the aforementioned publication) supports the same thesis that polyphenols, by generating H 2 O 2 , affect redox signaling and activate the NRF2 axis to ensure cell adaptation and survival

The prevalence of CAN among diabetes patients ranges from 20 to 60%

These enzymes are sensitive to metabolite concentrations and their activity directly influences epigenetic modifications (90)

Both isoforms are synthesized in the cytoplasm

"BPC" stands for "Body Protection Compound." In preclinical work it is proposed to act through several overlapping pathways, including promotion of new blood-vessel growth (angiogenesis), modulation of nitric-oxide signaling, and anti-inflammatory activity, rather than through one well-defined receptor mechanism the way a conventional small-molecule drug does