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10.1016/S0140-6736(12)62167-9 177

Nature 513 , 202209 (2014)

Environmental and physiological factors shape the gut microbiota of Atlantic salmon parr ( Salmo salar L.)

identified two new ALA metabolites, 9( Z )-13,16-DiOH-12(15)-EpOME and 9( Z )-7,13,16-TriOH-12(15)-EpOME, 247 and three new GLA metabolites, 6( Z ),9( Z )-12(17);13(17)-DiEpODE, 6( Z ),9( Z )-12,13,17-TriHODE, and 6( Z ),9( Z )-12-OH-13(16)-EpODE

In CRC, our findings further extend the oncogenic role of MFAP2 by demonstrating that it is secreted by CAFs and activates the FAK-ERK1/2 signaling pathway via ITGB8, culminating in ETS2-dependent upregulation of the cholesterol-metabolizing enzyme CYP27A1