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Changes in antioxidant enzyme and glutathione levels in diabetic patients suggest that these markers may be helpful in diagnosing and predicting disease progression

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Trial registration The study protocol was approved by the ethics committee of Guilan University of Medical Sciences (IR.GUMS.REC.1400.197) in accordance with the World Medical Associations code of ethics (Declaration of Helsinki, revised in Brazil 2013), and registered at an ICMJE and WHO recognized registry of clinical trials ( www.irct.ir ) on 28/08/2021 (registration number: IRCT20200920048782N1).

Larger trials with longer follow-up, however, are warranted to establish the effects.

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