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These reactions can compromise patient safety and limit the clinical applicability of these treatments

The pie charts above clearly show the difference in distribution in vitamin D levels among adults

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Moreover, there is significant granularity within bias, as a G protein-biased ligand may selectively activate some G proteins and not others, and a -arrestin-biased ligand may selectively activate some arrestin functions, such as internalization or signaling, and not others, such as desensitization [8991]