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Inhibition of PGHS can lead to accumulation of AA which in turn enhances cardiac mitochondrial dysfunction

Xie, Y., Lei, X., Zhao, G., Guo, R

Some research has safely used doses up to 90 grams daily for specific medical conditions, though such high amounts should only be used under medical supervision

We are grateful for the assistance of the Core Laboratories at School of Biomedical Sciences, the Chinese University of Hong Kong, and Histomorphometry and Molecular Analysis Core at the University of Alabama at Birmingham

This effect is probably due to coppers inhibition of CBS, promoting HCY elevation and halting glutathione synthesis (57)