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Moreover, astrocytes contribute toand to a large extent definecognitive reserve, which in turn influences the neurological and cognitive outcomes of all CNS disorders as well as physiological aging

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This modification leads to the remodeling of chromatin structure and the recruitment of DNA repair proteins, such as X-ray repair cross-complementing protein 1 (XRCC1), DNA ligases, and DNA polymerases (129, 130)

12 weeks (2 4 8 mg titration): ~3 vials 24 weeks (up to 12 mg weekly): ~9 vials 48 weeks (maintenance at 12 mg): ~21 vials Insulin Syringes (U-100, 1 mL) Per week: 1 syringe (once-weekly dosing) 12 weeks: 12 syringes 24 weeks: 24 syringes 48 weeks: 48 syringes Bacteriostatic Water (10 mL bottles) Use 2.4 mL per vial for reconstitution

These compounds have shown benefits in animal studies and early human trials