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doi: 10.1089/neu.1999.16.1067

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Nicotinamide-N-methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels

Serious side effects include severe pain, persistent nausea, vomiting, diarrhea, and rectal bleeding. Coffee enemas, like taking an aspirin or any other medicine, is potentially dangerous
