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Animal studies have shown that 95% hyperoxia substantially enhanced cellular ROS generation, increased apoptosis, induced TRX-1 and TRXR-1 expression while the TRXR-1 activity was reduced
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Folate-rich diet increased DNA methylation of genes such as p16 [114] in mouse colon and protooncogenes such as PDGF-B (platelet-derived growth factor-B), Ras (rat sarcoma), and survivin in a mouse model of gliomagenesis [115]
