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Glutathione depletion in mitochondria made them more sensitive to ROS production and subsequent oxidative stress

On the basis of the type of hexosamine, GAGs are classified into two main categories: glucosaminoglycans, including keratan sulfate (KS), heparin (HP), hyaluronic acid (HA), and heparan sulfate (HS), and galactosaminoglycans, such as chondroitin sulfate (CS) and dermatan sulfate (DS)

The xCT provides intracellular cystine, which is rapidly reduced to cysteine for GSH production

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Here, we performed detailed metabolic analysis of CMV-specific CD8 + T cells from KTRs with controlled and uncontrolled CMV infection