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These iron-catalyzed oxidants can further enhance inflammation transcription factors induced by protein and autoantibodies, leading to the production of matrix proteins, cytokines/chemokines, and immune cell infiltration
Furthermore, compounds such as isorhapontigenin have shown efficacy in decreasing oxidative damage in brain IRI through the PKC/Nrf2/HO-1 pathway, markedly lowering ROS generation and 4-HNE and 8-hydroxydeoxyguanosine levels (55)
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Cell 162 , 12171228 (2015)
