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**Lower cost** AOD-9604 was historically cheaper than GLP-1 medications However, the clinical reality is that AOD-9604 failed its pivotal weight loss trial

Unlike GLP-1 peptides like semaglutide , which frequently cause significant nausea as part of their mechanism of action, AOD 9604 does not suppress appetite or slow gastric emptying

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The 2024 NICE guideline NG239 sets out a more intensive loading schedule for patients with neurological involvement precisely because their starting point is worse