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Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig
doi: 10.1016/j.neuroscience.2004.09.053, 138 SimonD
[DOI] [PMC free article] [PubMed] [Google Scholar] Maerker G
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the mutated nucleotide is underlined
