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Healthy aging and muscle function are positively associated with NAD+ abundance in humans

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Because no studies have evaluated potential risks, such as effects on the fetus or pregnancy outcomes, clinicians advise against NAD+ therapy during pregnancy out of an abundance of caution

A single-nucleotide polymorphism (sA158G rs4680) in the COMT gene also led to a greater risk of LDopa-related PN in PwPD through low enzymatic activity (Toth et al
