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Smoking and Pollution Exposure Cigarette smoke introduces a massive amount of free radicals into the lungs and bloodstream, and pollution from traffic and industrial areas does the same

ZZW-15, an inhibitor of nuclear protein 1 (NUPR1), downregulates SLC7A11 and GPX4 mRNA levels and induces ferroptosis in MiaPaCa-2 cells [70]

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Additionally, the promoter of HSPA5 was activated in heat-shocked cells, yet the expression of dominant negative HSF1 (dnHSF1) did not abolish this induction, suggesting that heat shock-induced UPR ER is not controlled by HSF1

Microbial short-chain fatty acids and blood pressure regulation