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Cerebral ischemia triggers widespread activation of the peripheral immune system, releasing a large number of immune cells, inflammatory cytokines, and chemokines, which promote immune cell infiltration into the brain and further exacerbate brain injury (137)

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The authors also observed a marked decrease in vascular BH 4 content and identified the endothelium as the pivotal superoxide source compatible with eNOS uncoupling

489,490 Those in the major depression group had significantly increased abundance of Bacteroides and significantly decreased abundance of Blautia and Eubacterium

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