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BBB dysfunction also increases with aging, which is an important risk factor for COVID severity 48,49

C., Burch, J

Although astrocyte reactivity is likely in the first instance to be targeted at maintaining CNS homoeostasis and circuit functions, various mechanisms could alter astrocyte functions in potentially detrimental ways, including (i) persistent reactivity may contribute to chronic neurodegenerative disorders or chronic inflammation, (ii) ageing and cellular senescence which may alter and reduce astrocyte functional capacities, or (iii) genetic mutations in diseased astrocytes or polymorphisms may alter normal astrocyte functions or responses

Jimmy wrote a letter of complaint and quoted NICE, BNF (British National Formulary) and the NHS website and pled his case to receive proper care