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In a series of 181 patients with lumbar disc herniations in 65% of the cases the site of failure was the annulus endplate junction with bony changes or avulsions at the posterior rims of the endplates
Furthermore, the mitochondrial genome encodes transfer RNA (tRNA) and ribosomal RNA (rRNA) used for RNA translation [23]
An acid cleavable linker (acid labile linker) is a class of chemical linkers that can cleave under acidic conditions, commonly used in targeted drug delivery systems, especially antibody-drug conjugates (ADCs)

[5] Experimental findings suggest possible modulation of metalloproteinase expression, collagen-related gene activity, and antioxidant enzyme systems, supporting extracellular matrix turnover

Diabetologia 50 , 186194 (2007)