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This is achieved when the ER Ca 2+ -channel, the ryanodine receptor (RyR), is activated by the oxidation of its thiol (-SH) sites (Denniss et al

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Since the firewall knows that TCP/21 is used for FTP, it looks at the traffic, sees the PORT command, and changes it to PORT(50,60,70,2,x,y) and then listens on port x,y