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The installation and development of these diseases are closely linked to metabolic changes that generate a state of oxidative stress, due to the excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) [7,8]
Zhu H, Wang X, Meng X, Kong Y, Li Y, Yang C, et al

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The results indicated that N-terminal modifications were particularly effective at enhancing metabolic stability, whereas C-terminal amidation offered more modest protection

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