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They hypothesized that topiramate has a complex mechanism of action that includes antagonism of several Glu receptors, blockade of voltage-dependent Na + channels, and inhibition of carbonic anhydrase (Ma et al., 2013)

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Methods Study design and setting Data were obtained from the Netherlands Study of Depression and Anxiety (NESDA), an ongoing naturalistic longitudinal cohort study examining course and consequences of depressive and anxiety disorders

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