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doi: 10.1016/s0161-813x(02)00035-9
It involves collecting longitudinal blood and stool samples, along with questionnaires, from participants over a five-year period

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Moreover, compromised mitochondrial signaling reduces energy production and elevates ROS, which subsequently inflict damage upon endothelial cells and inhibit NO synthesis, thereby exacerbating the muscle-vascular dysfunction (25)

[DOI] [PubMed] [Google Scholar] Acosta M.F., Muralidhran P., Abrahamson M.D., Grijalva C.L., Carver M., Tang H., Klinger C., Fineman J.R., Black S.M., Mansour H.M
