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Consequently, exogenous HGH administration does not guarantee proportional IGF-1 elevationindividual variation in hepatic responsiveness can be substantial

doi: 10.1093/protein/13.10.703
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[DOI] [PMC free article] [PubMed] [Google Scholar] 213.Micheletto C., Izquierdo J.L., Avdeev S.N.R., Escobar R.A., Pacheco Gallego M.C

Despite the differences in their stimuli, both pathways share common mechanistic features, most notably the production of ROS via respiratory burst oxidase homologs (RBOHs) and subsequent activation of redox-sensitive signaling cascades
