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Nonetheless, it seems that it could have intracellular targets instead of only being proteolysed

doi:10.1016/j.ejphar.2020.172984 Annamaraju P, Baradhi KM

Further, a secondary analysis of a trial in women at high risk for or with existing cardiovascular disease reported that high-dose supplemental B-vitamins (1 mg/day of vitamin B 12 , 50 mg/day of vitamin B6, and 2.5 mg/day of folic acid) for 7.3 years had no effect on risk of non-vertebral fractures (122)

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Many patients felt strongly about this and let us know, he added