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Finally, the antioxidant effects of CBD were attributed to the overexpression of Nrf2 and the anti-apoptotic effects by reducing the expressions of Bax and Casp3 genes and upregulation of the Bcl-2 gene

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In addition to nucleotide biosynthesis, the nitrogen of glutamine in mammalian cells is also required to synthesize NAD, glucosamine6phosphate, a precursor for protein glycosylation, and asparagine, another nonessential amino acid (Richards & Schuster, 1998