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Th1 cells are activated by dendritic cells (DCs) that present antigens and secrete type 1 cytokines (IL-2, interferon- [IFN-], and IL-12), while Th2 cells are activated by DCs that present antigens and generate type 2 cytokines (IL-4, IL-10) to help B cells secrete protective antibodies
This is likely because naturopaths uncover the root cause of symptoms, rather than simply treating the symptoms (as many medical doctors do)

The how to reconstitute peptides guide provides additional context on why gentle handling matters

Dec 2017;34(12):1627-1632
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Could you put it on your face with your fingers