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In this case, ATP breaks down into lower energy phosphate compounds, ADP and AMP, the latter being prone to deamination to IMP by RBC-specific AMP deaminase 3 [94]

10.1038/ncomms2885 Nat

Cuproptosis increases the stability of NFE2L2 by suppressing its proteasomal degradation, leading to transcriptional upregulation of GCLC and GCLM and enhanced GSH synthesis, thereby suppressing cuproptosis in pancreatic cancer cells 169

Oncolytic virus therapy represents a promising modality wherein viruses are engineered to selectively infect and lyse tumor cells (200)

Standardization of time duration was performed in our previous experiments which showed that, 12 h duration (among the tested durations 1 h, 3 h, 6 h, 12 h, 24 h and 48 h) of hypoxia exposure was the optimum time, at which maximum renal damage had occurred 26