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Since ablation of NADPH blocked the protective effect of G6PD overexpression, we concluded that G6PD overexpression alleviates vascular aging through NADPH

As PHDs are 2-oxoglutarate (2-OG, -ketoglutarate)-dependent dioxygenases, chemical 2-OG analogs can be used for PHD inhibition and HIF- stabilization and can serve as leads for drug discovery targeting the HIF/EPO axis

Long-Term Safety Considerations While 24-week human trials provide reassurance about short-to-medium term safety, very long-term data (multi-year continuous use) is limited

2019 May;9(1 Suppl):77S-88S

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