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TIMERS for foot ulcersCurrent management strategy

Excessive NAM depletion directly reduces the substrate supply for NAD+ synthesis, leading to decreased intracellular NAD+ levels

- Lower Frequency: Typically, B12 shots are administered less frequently than oral supplements

The NHS symptoms list includes persistent tiredness, tingling or numbness in the hands and feet, mouth ulcers, a sore red tongue and problems with memory or concentration

In people with insulin resistance or type 2 diabetes, GLP1 and GIP activity can support glucose-dependent insulin secretion, which means insulin release increases mainly when glucose is elevated