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Changes in vessel diameter will drive changes in cerebrovascular resistance following the Hagen-Poiseuille equation and so affect blood flow

A GP or specialist can assess underlying health conditions that may increase the risk of adverse effects and can advise on licensed, evidence-based alternatives available through NHS or private prescribing pathways

Postural Tachycardia and Dizziness (POTS): By supporting the COMT enzyme's ability to clear excess adrenaline and supporting the autonomic nerves responsible for baroreceptor function, B12 may help stabilize heart rate upon standing and reduces the severity of hyperadrenergic adrenaline surges

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