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The mechanisms underlying muscle preservation likely involve tesofensine's enhancement of dopaminergic and noradrenergic signaling, which may support protein synthesis pathways and reduce muscle atrophy signaling
Owing to low sample size at the 30-min group ( n = 3) and unequal distribution, within-group analysis was done using Wilcoxon signed-rank test comparing the pre-scans and 120-min post-withdrawal scans
Nanoparticles exhibit advantages such as improved solubility of small molecule ferroptosis inducers, enhanced targeting specificity, lower systemic toxicity, controllable drug release, and synergistic effects with emerging therapies

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