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The pretreatment of cultured rat hepatocytes with UDCA significantly prevents the decrease in viability due to H 2 O 2 or cadmium administration [77]

There is also the question of immunogenicity, which refers to the ability of a substance to provoke an immune response

Erastin and RSL3 have been used as ferroptosis inducers in mostly in vitro experiments because of the limited in vivo bioavailability and reduced metabolic stability

104 In addition to the pharmacological classification and mechanistic insights into natural products used in GI health, numerous ethnobotanical and ethnopharmacological surveys across the globe provide compelling evidence of traditional plant use in treating a wide range of GI disorders

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