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[DOI] [PubMed] [Google Scholar] 78.Benvenga S, Lakshmanan M, Trimarchi F

Finally, one trial in 239 participants already suffering from chemotherapy-induced peripheral neuropathy reported a reduction in the severity of neuropathic symptoms with ALCAR (3 g/day for eight weeks) compared to placebo (93)

Most patients do see a moderate to very good improvement from Exilis

3 Resolution pharmacology to target fibroblasts 3.1 The resolution of inflammation at a glance Resolution Pharmacology is a type of therapeutic strategy based on the activation of endogenous mechanisms aimed at promoting homeostasis after a pro-inflammatory stimulus ( All these systems were discovered and extensively studied upon the realization that inflammatory responses are brought down to homeostatic levels by the active engagement of endogenous pathways rather than passively as previously believed ( Several mechanisms of resolution have been described, like the active reduction in cytokine release and prevention of cell recruitment, enhancement of macrophage efferocytosis, induction of macrophage class switch, promotion of granulocyte apoptosis, and the production of anti-inflammatory cytokines ( 3.2 Resolution pharmacology to target fibroblasts mediated diseases everal mediators and their derivatives, acting on various pro-resolving receptors have been tested in fibroblasts and in animal models of fibrosis

These molecules can be used as adjuvant treatment to reduce the amount of prescription medication needed (Chattopadhyaya et al., 2015, Koppula et al., 2012, Sedaghat et al., 2014)