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Current gaps include limited factorial trials, short follow-up, under-reporting of live births, and insufficient phenotype stratification

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Although hydroxychloroquine-based combinations have demonstrated acceptable safety profiles in early-phase studies, including NCT02432417 and NCT00486603, none have shown consistent or significant survival benefits in randomized or non-randomized settings

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This condition is implicated in various chronic diseases, including cardiovascular disorders, cancer, neurodegenerative diseases, autoimmune conditions, and diabetes mellitus