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2) Angiogenesis, because IGF-I is known to exert significant pro-angiogenic effects, inducing proliferation of microvascular endothelial cells in culture through HIF-1 and VEGF[291]
doi: 10.1073/pnas.2014441117
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Gfi1 cre/+ mice were then crossed with SIRT1 flox/flox mice to obtain SIRT1 conditional knockout ( SIRT1 CKO) mice
Gently massage in a circular motion until the cream splashes into water droplets
