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Acknowledgements This study was supported by the National Research Foundation (NRF) Grant (grant nos

11, 12, 13, 14, 15 Direct and indirect studies have demonstrated that oxidative stress from reactive oxygen species (ROS) generated through mitochondria, xanthine oxidase, and the NADPH oxidase system 16, 17, 18, 19, 20, 21 is one of the important factors in the pathogenesis of myocardial ischemia

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In this review, we will discuss these critical issues, providing a state of the art of the role of this protein in early PD and other synucleinopathies