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If significant fibrosis is confirmed, patients should be referred to a specialist to perform liver biopsy and confirm the diagnosis histologically ( Chronic inflammation is the driving force for the onset and progression of fibrosis in NASH ( 4

[5] [6] However, retatrutide remains an investigational compound and has not been approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA) for any clinical use

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Bang P, Thorell A, Carlsson-Skwirut C, Ljungqvist O, Brismar K, Nygren J