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Cell targeting was enhanced by using PEGs of different molecular weights such as PAM2 with molecular weights of 2000 and 10,000, PAM4 with a molecular weight of 20,000, and PSH2 with a molecular weight of 2000

Mutations in the Rb pathway include deletions in CDKN2A , which encodes p16, and amplifications of CDK4

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doi: 10.1210/en.2013-1002

Additionally, inhibition of SLC1A5-mediated glutamine transport by knockdown of SLC1A5 or adding SLC1A5 inhibitor L--glutamyl-p-nitroanilide (GPNA) attenuates mTOR activation and proliferation of breast cancer cells, and these inhibitory effects are more prominent in TNBC tumor cells compared to luminal subtypes (88)