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TDB and DLM gratefully acknowledge support from NIH Grant R01GM124270 supporting the SAMPL Blind challenges
However, neurotrophins have had little success in clinical trials directed at neurodegenerative diseases due to their poor pharmokinetic profile and large molecular weight that significantly impedes penetration of the BBB [61,62]

Cassano T, Magini A et al (2019) Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimers disease

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