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Pharmacokinetic studies in rats demonstrated an oral bioavailability of 38.4%, with a mean Cmax of 2,252 ng/mL and terminal elimination half-lives of 3.80 1.10 hours (IV) and 6.90 1.20 hours (oral) (Awosemo et al., 2021)

When you swallow a B12 pill, several steps have to work for it to be absorbed: stomach acid and the enzyme pepsin must release B12 from food or the supplement, the stomach must secrete a protein called intrinsic factor that binds to B12, and the B12-intrinsic factor complex must reach the ileum (the end of the small intestine) where it is finally absorbed