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Deletion of the JM domain also alters the conformation of the c-MET receptor, leading to constitutive activation of the kinase domain

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[DOI] [PMC free article] [PubMed] [Google Scholar] 646.Liu W, Liu R, Sun W, Peng Q, Zhang W, Xu E, Cheng Y, Ding M, Li Y, Hong Z, Wu J, Zeng J, Yao C, Huang Y, CASISP Study Group

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Thiamine deficiency adversely affects the activity levels of these enzymes, with TK, through thiamine-dependent erythrocyte transketolase (ETK) activity, common biomarkers of thiamine status, since it is particularly sensitive to thiamine levels and AKD often exhibiting the earliest detectable changes (41)