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Over time, this sustained immune activation results in chronic inflammation, which not only contributes to tissue damage but also fuels viral proliferation by providing a continuous supply of target cells, resulting in the gradual depletion of CD4+ T cells, hallmarking HIV progression

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Autophagy 15 , 151164 (2019)

These diseases share several core pathological features: Oxidative stress, neuroinflammation and mitochondrial dysfunction (74)

In summary, the identification of ferroptosis-related regulatorssuch as PTGS2, GPX4, and SLC7A11in SA-induced osteomyelitis positions ferroptosis as a promising and potentially druggable pathway