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Acute Myeloid Leukemia Expands Osteoprogenitor Rich Niche in the Bone Marrow but Resorbs Mature Bone Causing Osteopenia/Osteoporosis in Animal Models

The peptide clinic charging $400 per vial for a compound with 14 human subjects studied has the same economic incentives as the pharmaceutical company charging $400 per month for a branded statin

TargetP2.0 (T) [46], LOCALIZER (L) [47] and PredAlgo (P) [48] targeting predictions (Additional file 1 Table S1) are indicated (M, mitochondria

Additionally, caffeine exhibits antioxidant properties and immunomodulatory potential, making it an important target for anti-inflammatory effects [22, 23]

GUSAR software was used to estimate the acute toxicity of selected compound, which provided LD 50 values for different administration routes (intraperitoneal, intravenous, oral, and subcutaneous) in rats