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This work was supported by the National Natural Science Foundation of China, China (82100405 to Q.H., 81703499 to D.W.), Science and Technology Commission of Shanghai Municipality, China (22ZR1456900 to D.W.), Shanghai Municipal Health Commission, China (2022YQ053 to D.W., 20214Y0268 to F.M.), Shanghai Pujiang Program, China (2020PJD055 to D.W.), Shuguang Hospital Research Funding Project, China (SG3915 to B.T.), Youth Innovation Promotion Association of Chinese Academy of Sciences (2020425 to T.C.), American Heart Association (18EIA33900041 to W.W.), Open Project of Qinghai Key Laboratory of Qinghai-Tibet Plateau Biology Resources (T.C

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10.1186/1471-2288-14-43 37 JadiyaP.CohenH